ByFarly Powell 2020-02-03 773
According to the public information, the whole genome sequence of the new coronavirus is 29847bp, and the clinical diagnosis needs to compare the patient samples with the virus gene sequence in order to determine the diagnosis result. At present, nucleic acid detection method is widely used in hospitals, which can only detect the local part of the virus gene. Because of the possibility of virus mutation, this detection method is like a blind person touching an elephant for the whole gene sequence. once the virus mutates, it may fail to detect.
After the outbreak of the new coronavirus pneumonia, Dr. Gu Fei, an algorithm expert at Dharma Hospital, immediately rushed to the Center for Disease Control and Prevention in Zhejiang Province to analyze the characteristics of the new coronavirus gene and put forward a number of algorithm models. In the process of sequence alignment, the Dharma Institute adds a distributed design to the algorithm to effectively improve the alignment efficiency; in the virus sequence splicing stage, using the distributed design de Bruijn diagram algorithm, mutated viruses can also be accurately detected.
The automated whole-genome detection and analysis platform uses the whole-genome detection technology which is different from the nucleic acid detection method to analyze and compare the whole genome sequence of the virus samples of suspected cases, which can effectively prevent the missed detection caused by virus mutation. After the platform is online, the original hours of genetic analysis of suspected cases can be shortened to half an hour, the time for diagnosis can be greatly shortened, and the variation of the virus can be accurately detected. Greatly improve the speed and accuracy of diagnosis of suspected cases.
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